Scientific Programme

1st World NET Forum

Took place as a Hybrid Event on 8 - 9 March 2022

in Barcelona, Spain

Programme

8 - 9 March 2022 - Hybrid Event

Tuesday, 08 March 2022

Welcome

Time: Tuesday 11:00 - 11:10
Marianne Pavel, GER /

Session 1: Models in NET research

Time: Tuesday 11:10 - 12:20
Chairs: Jie Chen, CHN / Anne Couvelard, FRA / Simron Singh, CAN /
11:10 - 11:40 Keynote address: An organoid biobank of neuroendocrine neoplasms enables genotype-phenotype mapping
Kenta Kawasaki, JPN /
11:40 - 12:00 Talk 1: State-of-the-art NET tumor models: Present & future
Dawn Quelle, USA /
12:00 - 12:20 Discussion

Coffee break

Time: Tuesday 12:20 - 12:50

Session 2: NET tumor biology advances

Time: Tuesday 12:50 - 14:45
Chairs: Emily Bergsland, USA / Aurel Perren, SUI /
12:50 - 13:20 Keynote address: Understanding tumor biology of NEN by integrated genomic analysis
Aldo Scarpa, ITA /
13:20 - 13:30 Discussion
13:30 - 13:45 Talk 1: Epigenetic control of human intestinal neuroendocrine cell differentiation
Ramesh Shivdasani, USA /
13:45 - 13:55 Discussion
13:55 - 14:10 Talk 2: Immune and stromal heterogeneity associated with cellular origin and cancer evolution in GEP-NET
Anguraj Sadanandam, GBR /
14:10 - 14:20 Discussion
14:20 - 14:35 Talk 3: Mechanisms of RB loss in neuroendocrine carcinoma
Nancy Joseph, USA /
14:35 - 14:45 Discussion

Summary of sessions 1 & 2

Time: Tuesday 14:45 - 15:00
Justo P. Castaño, ESP /

Coffee break

Time: Tuesday 15:00 - 15:30

Oral abstract presentations - Part I

Time: Tuesday 15:30 - 16:55
Chairs: Hironobu Sasano, JPN / Ramesh Shivdasani, USA /
15:30 - 15:40 Characterising aggressive pulmonary carcinoids through integrative omics analysis
Alexandra Sexton-Oates, FRA /
15:40 - 15:50 Discussion
15:50 - 16:00 Broncho-pulmonary combined large-cell neuroendocrine carcinomas (Co-LCNEC): More than a hybrid neoplasm
Michele Simbolo, ITA /
16:00 - 16:10 Discussion
16:10 - 16:20 Molecular, histopathological, and functional characterization of the dysregulation of the splicing machinery in lung carcinoids
Víctor García Vioque, ESP /
16:20 - 16:30 Discussion
16:30 - 16:40 Comprehensive transcriptomic and methylomic analysis of NENs from multiple origins show subgroups of patients with clinical relevance
Carlos Carretero, ESP /
16:40 - 16:50 Discussion
16:50 - 16:55 Summary - Part I

Coffee break

Time: Tuesday 16:55 - 17:15

Oral abstract presentations - Part II

Time: Tuesday 17:15 - 19:00
Chairs: Douglas Hanahan, SUI / Eva Tiensuu Janson, SWE /
17:15 - 17:25 Molecular deciphering of primary liver neuroendocrine neoplasms confirms its distinct existence with foregut-like profile
Louis de Mestier, FRA /
17:25 - 17:35 Discussion
17:35 - 17:45 Epigenetic ageing and metabolic traits of multi-focal ileal neuroendocrine tumors
Amy Webster, GBR /
17:45 - 17:55 Discussion
17:55 - 18:05 Tumor neoantigens shape the immune microenvironment of panNETs: An in silico analysis
Mauro Cives, ITA /
18:05 - 18:15 Discussion
18:15 - 18:25 Epigenetic progression steps in alpha-lineage MEN1-DAXX/ATRX mutated Pancreatic Neuroendocrine Tumors (PanNET)
Ilaria Marinoni, SUI /
18:25 - 18:35 Discussion
18:35 - 18:45 Novel patient-derived tumor organoid models reveal growth-factor dependencies in neuroendocrine tumors and serve as a platform for neuroendocrine cancer research
Talya Dayton, NED /
18:45 - 18:55 Discussion
18:55 - 19:00 Summary - Part II

Wednesday, 09 March 2022

Welcome

Time: Wednesday 11:00 - 11:10

Session 3: Therapeutic advances in NET

Time: Wednesday 11:10 - 12:40
Chairs: Bertram Wiedenmann, GER / Hong Zhao, CHN /
11:10 - 11:40 Keynote address: Deciphering NET tumor invasiveness to potentiate real therapy candidates
Douglas Hanahan, SUI /
11:40 - 11:50 Discussion
11:50 - 12:05 Talk 1: From genomics to functional genomics: The discovery and targeting of ATRX and MEN1 mutations in PanNETs
Yuchen Jiao, CHN /
12:05 - 12:15 Discussion
12:15 - 12:30 Talk 2: Mechanisms of resistance to PRRT and overcoming these
Rod Hicks, AUS /
12:30 - 12:40 Discussion

Coffee break

Time: Wednesday 12:40 - 13:10

Session 4: Novel areas in NET diagnostic and therapy

Time: Wednesday 13:10 - 14:40
Chairs: B.A. Krishna, IND / Kjell Öberg, SWE / Hironobu Sasano, JPN /
13:10 - 13:40 Keynote address: Precision oncological approach in neuroendocrine tumors (lessons from NET and other cancers)
Andrea Califano, USA /
13:40 - 13:50 Discussion
13:50 - 14:05 Talk 1: New radionuclides for improved diagnosis and therapy in NET
Cristina Müller, SUI /
14:05 - 14:15 Discussion
14:15 - 14:30 Talk 2: CAR-T cell technology
Xianxin Hua, USA /
14:30 - 14:40 Discussion

Summary of the day

Time: Wednesday 14:40 - 14:55
Marianne Pavel, GER /

Closing comments

Time: Wednesday 14:55 - 15:05
Marianne Pavel, GER /